Abstract | INTRODUCTION: METHODS: RESULTS: Median follow-up was 19.48 months. On univariate analysis, a lower IP VEGF taken just after incision (T1) was associated with improved overall (P = 0.0004) and disease-free survival (P = 0.0006) at 2 years. A lower T1/IV VEGF ratio also was associated with improved overall (P = 0.004) and disease-free survival (P = 0.0051). On multivariate analysis, a lower T1 was associated with improved overall survival, whereas a lower T1/IV VEGF was associated with improved disease-free survival. On subset analysis, these two variables were associated with improved survival in colorectal cancers. CONCLUSIONS: A lower IP VEGF level prior to surgery is associated with improved survival. The use of preoperative intraperitoneal bevacizumab for patients with a heavy disease load should be considered, especially in colorectal cancers.
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Authors | Claramae Shulyn Chia, Olivier Glehen, Naoual Bakrin, Evelyne Decullier, Benoit You, François Noël Gilly, Guillaume Passot |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 22 Suppl 3
Pg. S880-7
(Dec 2015)
ISSN: 1534-4681 [Electronic] United States |
PMID | 26040606
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Biomarkers, Tumor
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Bevacizumab
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Topics |
- Adult
- Aged
- Angiogenesis Inhibitors
(therapeutic use)
- Ascitic Fluid
(metabolism)
- Bevacizumab
(therapeutic use)
- Biomarkers, Tumor
(blood)
- Female
- Follow-Up Studies
- Humans
- Injections, Intraperitoneal
- Male
- Middle Aged
- Neoplasm Staging
- Neoplasms
(blood, drug therapy, pathology)
- Peritoneal Neoplasms
(blood, drug therapy, secondary)
- Prognosis
- Survival Rate
- Vascular Endothelial Growth Factor A
(blood)
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