Dispositions and tissue depletion of melamine in ducks.

Abstract

To evaluate the toxicokinetics and persistence of residues of melamine (MEL) in ducks, MEL was administered intravenously (i.v.) or orally (p.o.) to ducks at a dosage of 5.5 mg/kg body weight. The concentration of MEL in the plasma and various tissues was detected using HPLC equipped with an ultraviolet detector. The plasma concentration of MEL in ducks was determined up to 12 h after both i.v. and p.o. administrations. The average value of elimination half-life (t₁/₂β) of MEL was 2.16 ± 0.37 and 2.01 ± 0.56 h after i.v. and p.o. administration, respectively. The absolute p.o. bioavailability was 90.79%. MEL was measurable in the liver and kidney after p.o. administration with maximum levels of 15.80 ± 1.81 and 15.49 ± 2.12 μg/g at 6 h, respectively. The results suggest that most of the administered MEL is efficiently absorbed from the gastro intestinal tract, and it has the ability to distribute into various tissues of the duck.

• Authors: P Suknikom, U Jermnak, S Poapolathep, S Isariyodom, M Giorgi, S Kumagai, A Poapolathep
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 39 Issue 1 Pg. 90-4 (Feb 2016) ISSN: 1365-2885 [Electronic] England
• PMID: 26012473 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons Ltd.

Chemical References

• Triazines
• melamine

Topics

• Animals
• Area Under Curve
• Drug Residues
• Ducks (blood, metabolism)
• Half-Life
• Male
• Tissue Distribution
• Triazines (pharmacokinetics, toxicity)