A case of intravascular lymphoma diagnosed in an explanted liver after liver transplantation.

Abstract

Intravascular lymphoma (IVL) is a rare form of B-cell lymphoma. We encountered a rare case of IVL diagnosed in an explanted liver. A 49-year-old man visited a clinic with high fever. Because of elevated liver function, he was diagnosed with acute liver failure. Deceased donor liver transplantation (LT) was performed 16 days after admission. The post-transplantation course was uneventful until IVL was reported in the explanted liver on postoperative day (POD) 21. Rituximab was administered on POD 27, and rituximab-cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone (R-CHOP) treatment administered on POD 38. The R-CHOP treatment was repeated for eight cycles, and the patient remains free of recurrence 1 year post-transplantation. Although systemic lymphoma is a contraindication to transplantation, our experience indicates that IVL can be successfully treated by the administration of prompt chemotherapy after LT for fulminant hepatitis.

• Authors: Kaori Kuramitsu, Takumi Fukumoto, Yoshihiko Yano, Hirotaka Hirano, Takuyo Misumi, Yosio Katayama, Hiroki Kawano, Kimikazu Yakushijin, Yoh Zen, Tomoo Itoh, Yonson Ku
• Journal: Transplant international : official journal of the European Society for Organ Transplantation (Transpl Int) Vol. 28 Issue 10 Pg. 1245-50 (Oct 2015) ISSN: 1432-2277 [Electronic] Switzerland
• PMID: 26010984 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2015 Steunstichting ESOT.

Chemical References

• Antigens, CD20
• Antigens, Neoplasm
• Immunosuppressive Agents
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Acute Disease
• Antigens, CD20 (analysis)
• Antigens, Neoplasm (analysis)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Blood Vessels (pathology)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Gallbladder (blood supply)
• Hemangioma (complications)
• Hepatic Encephalopathy (etiology)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Incidental Findings
• Liver (blood supply, pathology)
• Liver Failure (etiology, surgery)
• Liver Neoplasms (complications)
• Liver Transplantation
• Lymphoma, B-Cell (complications, diagnosis, drug therapy)
• Male
• Middle Aged
• Neoplasm Invasiveness
• Neoplasms, Multiple Primary (diagnosis, drug therapy)
• Postoperative Complications (diagnosis, drug therapy)
• Prednisone (administration & dosage)
• Purpura, Thrombocytopenic, Idiopathic (complications, drug therapy, surgery)
• Respiratory Tract Infections (complications)
• Rituximab (administration & dosage)
• Splenectomy
• Transplants (pathology)
• Vincristine (administration & dosage)