Changes in choroidal thickness after intravitreal dexamethasone implant injection in retinal vein occlusion.

Abstract

AIMS:

To investigate the choroidal thickness changes in eyes with retinal vein occlusion (RVO) and to determine the effect of an intravitreal dexamethasone implant (Ozurdex) on choroidal thickness.

METHODS:

This study comprised 47 patients diagnosed with unilateral, RVO-associated macular oedema (MO) and treated with Ozurdex. Baseline subfoveal choroidal thickness (SFCT) and central macular thickness (CMT) of the RVO eyes were compared with those of the normal contralateral eyes; serial changes in this parameter were evaluated at 1, 3 and 5 months after Ozurdex injection. The correlation between SFCT and CMT and between visual acuity change and SFCT or CMT changes were also investigated.

RESULTS:

The mean SFCT was significantly higher in RVO eyes at baseline (260.3 ± 71.2 μm) than it was in contralateral eyes (217.6 ± 55.3 μm; p < 0.001). While the mean SFCT decreased at 1 and 3 months after Ozurdex injection, it slightly increased at month 5. The change in SFCT was significantly associated with the change in CMT at 3 months (r = 0.5073; p = 0.0006) and 5 months after Ozurdex injection (r = 0.3489; p = 0.0274). The improvement in visual acuity was significantly correlated with the decrease in SFCT (r = 0.3241; p = 0.0413).

CONCLUSIONS:

SFCT in eyes with RVO was significantly greater than it was in normal contralateral eyes. After Ozurdex injection, SFCT decreased significantly. Improvement in visual acuity was correlated with the decrease in SFCT after Ozurdex injection.

• Authors: Eun Kyoung Lee, Jeong Mo Han, Joon Young Hyon, Hyeong Gon Yu
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 99 Issue 11 Pg. 1543-9 (Nov 2015) ISSN: 1468-2079 [Electronic] England
• PMID: 25883084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Chemical References

• Drug Implants
• Glucocorticoids
• Dexamethasone

Topics

• Adult
• Aged
• Aged, 80 and over
• Axial Length, Eye (pathology)
• Choroid (pathology)
• Dexamethasone (administration & dosage)
• Drug Implants
• Female
• Glucocorticoids (administration & dosage)
• Humans
• Intravitreal Injections
• Macular Edema (diagnosis, drug therapy)
• Male
• Middle Aged
• Organ Size
• Prospective Studies
• Retina (pathology)
• Retinal Vein Occlusion (diagnosis, drug therapy)
• Tomography, Optical Coherence
• Visual Acuity (physiology)