Abstract | OBJECTIVE: This meta-analysis aimed to determine the relationships between XRCC1 Arg399Gln (rs25487 G>A) and XPD Lys751Gln (rs1052559 A>C) polymorphisms and susceptibility to age-related cataract. METHODS: RESULTS: Six independent case-control studies were included in the meta-analysis. Our results indicated that the association between the genetic polymorphisms of XRCC1 Arg399Gln G>A and XPD Lys751Gln A>C and increased susceptibility to age-related cataracts was statistically significant (XRCC1 Arg399Gln: OR=1.30, 95% CI=1.17-1.44, p<0.001; XPD Lys751Gln: OR=1.25, 95% CI=1.12-1.40, p<0.001, respectively). Ethnicity-stratified analysis indicated that the XRCC1 Arg399Gln G>A polymorphism was correlated with the development and progression of age-related cataract in China, India, and Turkey in the allele model and the dominant model. For the XPD Lys751Gln A>C variant, the association with the pathogenesis of age-related cataract in China and Turkey in the allele model and the dominant model was investigated. CONCLUSIONS: The association of XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms with age-related cataract susceptibility observed in our meta-analyses supports the view that XRCC1 and XPD may play important roles in susceptibility to age-related cataract.
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Authors | Xin-Xin Chi, You-Yu Liu, Su-Ning Shi, Zhuang Cong, Yu-Qing Liang, Hui-Jun Zhang |
Journal | Molecular vision
(Mol Vis)
Vol. 21
Pg. 335-46
( 2015)
ISSN: 1090-0535 [Electronic] United States |
PMID | 25873778
(Publication Type: Journal Article, Meta-Analysis)
|
Chemical References |
- DNA-Binding Proteins
- X-ray Repair Cross Complementing Protein 1
- XRCC1 protein, human
- Xeroderma Pigmentosum Group D Protein
- ERCC2 protein, human
|
Topics |
- Aged
- Aging
(genetics, pathology)
- Case-Control Studies
- Cataract
(genetics, pathology)
- DNA-Binding Proteins
(genetics)
- Female
- Gene Expression
- Genetic Predisposition to Disease
- Humans
- Male
- Models, Genetic
- Odds Ratio
- Polymorphism, Genetic
- X-ray Repair Cross Complementing Protein 1
- Xeroderma Pigmentosum Group D Protein
(genetics)
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