R-CHOP therapy alone for limited-stage follicular lymphoma.

Abstract

Irradiation therapy alone is a standard strategy for limited-stage FL, leading to a 10-year progression-free survival (PFS) rate of 30-50%. However, we have been administering R-CHOP therapy alone to patients with limited-stage FL. A total of 35 patients with newly diagnosed FL received R-CHOP therapy with curative intent between 2002 and 2009. The median age of the 35 patients was 61 years; 7 patients had in CS 1 FL, and 28 patients, CS 2 FL. The median number of R-CHOP cycles was 6. On completion of the R-CHOP therapy, 33 patients achieved complete response and 1 showed partial response (PR). The patient showing PR after the completion of R-CHOP was administered additional irradiation. The remaining 1 patient was not evaluated because of discontinuation of hospital visit. In all the 35 patients, the 5-year PFS rate was 70%, and the 5-year overall survival rate was 92%. In the 15 patients with a PFS>5 years, only 1 patient showed disease progression. The outcome of R-CHOP therapy alone in patients with limited-stage FL was at least equivalent to the reported outcome of irradiation therapy alone. R-CHOP therapy could be an alternative to irradiation therapy in limited-stage FL patients.

• Authors: Naoto Tomita, Taisei Suzuki, Yasufumi Ishiyama, Kazuho Miyashita, Hiroyuki Takahashi, Ayumi Numata, Satomi Ito, Kenji Motohashi, Takayoshi Tachibana, Hirotaka Takasaki, Rika Kawasaki, Maki Hagihara, Chizuko Hashimoto, Etsuko Yamazaki, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Shin Fujisawa, Shigeki Motomura, Yoshiaki Ishigatsubo
• Journal: Leukemia research (Leuk Res) Vol. 39 Issue 6 Pg. 582-5 (Jun 2015) ISSN: 1873-5835 [Electronic] England
• PMID: 25866096 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• R-CHOP protocol
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal, Murine-Derived (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Disease-Free Survival
• Doxorubicin (administration & dosage)
• Female
• Humans
• Lymphoma, Follicular (drug therapy, mortality)
• Male
• Middle Aged
• Neoplasm Staging
• Prednisone (administration & dosage)
• Rituximab
• Survival Rate
• Vincristine (administration & dosage)