Efficacy of a combined in-office/home-use desensitizing system containing 8% arginine and calcium carbonate in reducing dentin hypersensitivity: an 8-week randomized clinical study.

Abstract

PURPOSE:

To determine the efficacy in reducing dentin hypersensitivity (DHS) of a combined in-office and home-use desensitizing system, each product containing 8% arginine and calcium carbonate (Test), following a dental scaling procedure, compared to the combination of a conventional prophylactic paste and a potassium nitrate dentifrice (Control), in a group of patients with known dentin hypersensitivity.

METHODS:

An 8-week clinical study, with 50 subjects, was conducted in Piracicaba, São Paulo, Brazil, using a double-blind/two treatment design. Air blast sensitivity assessments were used to compare the efficacy of the two approaches using both the Schiff scale as well as a Visual Analogue Scale (VAS).

RESULTS:

Immediately after prophylaxis, the Test treatment provided significant reduction in DHS when compared to baseline values (VAS = 26.2% and Schiff = 29.1%), while for Control treatment this difference was not statistically significant (VAS = 8.1% and Schiff = 6.6%). The comparison between groups after prophylaxis showed a greater DHS reduction for the Test treatment (P < 0.05). The reductions in DHS after 2, 4 and 8 weeks were significant for both groups, however, when considering Schiff scale, the Test treatment provided greater DHS reduction after 2 weeks (44.5% for Test versus 27.7% for Control) and 4 weeks (55.2% for Test and 40.5% for Control), while after 8 weeks there was no significant difference between groups (71.1% for Test versus 61.1% for Control).

• Authors: Isabela Lima França, Enilson Antonio Sallum, Hugo Felipe Do Vale, Márcio Zaffalon Casati, Antonio Wilson Sallum, Bernal Stewart
• Journal: American journal of dentistry (Am J Dent) Vol. 28 Issue 1 Pg. 45-50 (Feb 2015) ISSN: 0894-8275 [Print] United States
• PMID: 25864242 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Dentin Desensitizing Agents
• Nitrates
• Phosphates
• Potassium Compounds
• Toothpastes
• pro-argin
• Arginine
• Calcium Carbonate
• Fluorides
• potassium nitrate

Topics

• Adult
• Aged
• Arginine (therapeutic use)
• Calcium Carbonate (therapeutic use)
• Dental Offices
• Dental Scaling
• Dentin Desensitizing Agents (therapeutic use)
• Dentin Sensitivity (diagnosis, prevention & control)
• Double-Blind Method
• Female
• Fluorides (therapeutic use)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nitrates (therapeutic use)
• Pain Measurement (methods)
• Phosphates (therapeutic use)
• Potassium Compounds (therapeutic use)
• Prospective Studies
• Self Care
• Toothpastes (therapeutic use)
• Treatment Outcome
• Visual Analog Scale
• Young Adult