Abstract | PURPOSE: Few studies to date have evaluated factors associated with the development of radiation pneumonitis (RP) in patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), especially in patients treated with contemporary radiation techniques. These patients represent a unique group owing to the often large radiation target volumes within the mediastinum and to the potential to receive several lines of chemotherapy that add to pulmonary toxicity for relapsed or refractory disease. Our objective was to determine the incidence and clinical and dosimetric risk factors associated with RP in lymphoma patients treated with intensity modulated radiation therapy (IMRT) at a single institution. METHODS AND MATERIALS: We retrospectively reviewed clinical charts and radiation records of 150 consecutive patients who received mediastinal IMRT for HL and NHL from 2009 through 2013. Clinical and dosimetric predictors associated with RP according to Radiation Therapy Oncology Group (RTOG) acute toxicity criteria were identified in univariate analysis using the Pearson χ(2) test and logistic multivariate regression. RESULTS: Mediastinal radiation was administered as consolidation therapy in 110 patients with newly diagnosed HL or NHL and in 40 patients with relapsed or refractory disease. The overall incidence of RP (RTOG grades 1-3) was 14% in the entire cohort. Risk of RP was increased for patients who received radiation for relapsed or refractory disease (25%) versus those who received consolidation therapy (10%, P=.019). Several dosimetric parameters predicted RP, including mean lung dose of >13.5 Gy, V20 of >30%, V15 of >35%, V10 of >40%, and V5 of >55%. The likelihood ratio χ(2) value was highest for V5 >55% (χ(2) = 19.37). CONCLUSIONS:
|
Authors | Chelsea C Pinnix, Grace L Smith, Sarah Milgrom, Eleanor M Osborne, Jay P Reddy, Mani Akhtari, Valerie Reed, Isidora Arzu, Pamela K Allen, Christine F Wogan, Michele A Fanale, Yasuhiro Oki, Francesco Turturro, Jorge Romaguera, Luis Fayad, Nathan Fowler, Jason Westin, Loretta Nastoupil, Fredrick B Hagemeister, M Alma Rodriguez, Sairah Ahmed, Yago Nieto, Bouthaina Dabaja |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 92
Issue 1
Pg. 175-82
(May 01 2015)
ISSN: 1879-355X [Electronic] United States |
PMID | 25863764
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Copyright | Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Bleomycin
- Vinblastine
- Dacarbazine
- Doxorubicin
|
Topics |
- Adolescent
- Adult
- Analysis of Variance
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bleomycin
(therapeutic use)
- Dacarbazine
(therapeutic use)
- Doxorubicin
(therapeutic use)
- Female
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Hodgkin Disease
(drug therapy, radiotherapy)
- Humans
- Lung
(radiation effects)
- Lymphoma, Non-Hodgkin
(drug therapy, radiotherapy)
- Male
- Mediastinal Neoplasms
(drug therapy, radiotherapy)
- Middle Aged
- Radiation Pneumonitis
(etiology)
- Radiotherapy Dosage
- Radiotherapy Planning, Computer-Assisted
(methods)
- Radiotherapy, Intensity-Modulated
(adverse effects)
- Regression Analysis
- Retrospective Studies
- Salvage Therapy
(adverse effects, methods)
- Vinblastine
(therapeutic use)
- Young Adult
|