Gender-specific effects of CGP 55845, GABAB receptor antagonist, on neuromuscular coordination, learning and memory formation in albino mouse following neonatal hypoxia-ischemia insult.

Abstract

GABAB receptor antagonists are experimentally proved as spatial memory enhancers in mouse models but their role has not been described following hypoxic-ischemic insult. 10-day-old albino mice were subjected to Murine model of hypoxia and ischemia. Following brain damage, mice were fed on normal rodent diet till they were 13 weeks old. At this time point, mice were divided into two groups. Group 1 received saline and group 2 received intraperitoneally CGP 55845 (1 mg/ml solvent/Kg body weight) for 12 days. Behavioural observations were made during rota rod, open field and Morris water maze test along with brain infarct measurement in both CGP 55845 treated and untreated groups. It was observed that application of GABAB receptor antagonist improved the over all motor function in male and female albino mice but effects were more pronounced in males. In open field, CGP 55845-treated female mice showed poor performance. CGP 55845 had no significant effect on learning and memory formation during Morris water maze test and also on brain infract size in both genders following hypoxia ischemia encephalopathy. Effects of CGP 55845 can be further explored in a dose and duration dependent manner to improve the learning and memory in albino mice following neonatal brain damage.

• Authors: Quratul Ane Gillani, Atif Akbar, Muhammad Ali, Furhan Iqbal
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 36 Issue 6 Pg. 961-9 (Jun 2015) ISSN: 1590-3478 [Electronic] Italy
• PMID: 25847084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• GABA-B Receptor Antagonists
• Phosphinic Acids
• Propanolamines
• CGP 55845A

Topics

• Animals
• Animals, Newborn
• Behavior, Animal (drug effects)
• Brain (drug effects, physiopathology)
• Disease Models, Animal
• Female
• GABA-B Receptor Antagonists (pharmacology)
• Hypoxia-Ischemia, Brain (drug therapy)
• Ischemia (drug therapy, physiopathology)
• Male
• Maze Learning (drug effects)
• Memory (drug effects)
• Mice
• Phosphinic Acids (pharmacology)
• Propanolamines (pharmacology)
• Sex Characteristics