Successful Pregnancy After Sacrectomy Combined With Chemotherapy and Radiation for Ewing Sarcoma: Case Report and Literature Review.

Abstract

BACKGROUND:

Ewing sarcoma is considered to have a poor prognosis. Recent advances in multidisciplinary management have resulted in a marked improvement in long-term survival.

CASE:

We describe a case of successful pregnancy in a patient who underwent sacrectomy combined with multi-agent chemotherapy and radiotherapy for Ewing sarcoma. The patient was diagnosed with Ewing sarcoma of the sacrum at the age of 16. The ovaries were transposed, the uterus was shielded, and a gonadotropin-releasing hormone agonist was used during treatment to protect ovarian function. The patient spontaneously conceived at the age of 27. After an uneventful pregnancy, the patient delivered a healthy neonate at term by cesarean section.

SUMMARY AND CONCLUSIONS:

Successful pregnancy and delivery can be achieved after multi-modality treatment with pretreatment intervention for fertility preservation.

• Authors: Jun Kakogawa, Takafumi Nako, Kazuhiro Kawamura, Shin Nakamura, Ayako Mochiduki, Naohiro Kanayama, Mamoru Tanaka
• Journal: Journal of pediatric and adolescent gynecology (J Pediatr Adolesc Gynecol) Vol. 28 Issue 3 Pg. e79-81 (Jun 2015) ISSN: 1873-4332 [Electronic] United States
• PMID: 25823720 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols
• Bone Neoplasms (drug therapy, radiotherapy, surgery)
• Cesarean Section
• Chemotherapy, Adjuvant
• Female
• Humans
• Infant, Newborn
• Neoadjuvant Therapy
• Neoplasm Recurrence, Local (drug therapy, surgery)
• Pregnancy
• Radiotherapy, Adjuvant
• Sacrum (surgery)
• Sarcoma, Ewing (drug therapy, radiotherapy, surgery)