Efficacy of rotational thrombectomy on the mortality of patients with massive and submassive pulmonary embolism.

Abstract

BACKGROUND:

Pulmonary embolism (PE) associated with hemodynamic instability has exceedingly high mortality. We describe our experience using percutaneous mechanical thrombectomy (PMT) in patients with massive PE (MPE) and submassive PE (SPE).

METHODS:

Thirty-six patients (16 males and 20 females; mean age, 51.4 ± 6.6 years) with massive and submassive PE were treated with PMT. All patients exhibited acute symptoms and computed tomography evidence of large thrombus burden and evidence of right ventricular (RV) dysfunction and/or failure. An Aspirex® percutaneous aspiration device was used in all patients. Clinical outcomes, hemodynamic recovery, RV and pulmonary artery pressures (PAP), blood gas changes, thrombus clearance, and complications were evaluated.

RESULTS:

Treatment of 36 patients resulted in complete thrombus clearance (≥ 90%) in 83.3% of the patients (n = 30) and near-complete (50% to 90%) clearance in 13.8%. Measurements before and after treatment showed a decrease in mean PAP (53 ± 5.8 mmHg versus 25.6 ± 6.3 mmHg in MPE group [p < 0.01] and 46 ± 7.7 versus 22 ± 3.6 in SPE group [p < 0.01]). One patient died from refractory shock. No cardiovascular deaths or recurrent PE were documented during clinical follow-up but one patient demonstrated evidence of mild cor pulmonale.

CONCLUSIONS:

This study demonstrates safety and effectiveness of percutaneous mechanical aspiration thrombectomy in patients with massive and submassive PE with a large thrombus burden.

• Authors: Mert Dumantepe, Burak Teymen, Ulku Akturk, Mustafa Seren
• Journal: Journal of cardiac surgery (J Card Surg) Vol. 30 Issue 4 Pg. 324-32 (Apr 2015) ISSN: 1540-8191 [Electronic] United States
• PMID: 25683156 (Publication Type: Journal Article)
• Copyright: © 2015 Wiley Periodicals, Inc.

Topics

• Aged
• Arterial Pressure
• Female
• Follow-Up Studies
• Hemodynamics
• Humans
• Male
• Middle Aged
• Pulmonary Artery (physiopathology)
• Pulmonary Embolism (diagnostic imaging, mortality, physiopathology, therapy)
• Severity of Illness Index
• Suction (instrumentation, methods)
• Thrombectomy (instrumentation, methods)
• Tomography, X-Ray Computed
• Treatment Outcome
• Ventricular Dysfunction, Right (diagnostic imaging, etiology)