Abstract | BACKGROUND: METHODS: Data were retrospectively collected for 215 patients with ICC who underwent liver resection during the years 1995-2012. Patients were divided into those (n = 102; 47.4%) who received LND (LN [D]) and those (n = 113; 52.6%) who did not (LN [D0]). RESULTS: Demographic data were similar between the 2 groups except for presence of preoperative symptom (P = .019) and liver cirrhosis (P < .001), carbohydrate antigen 19-9 (P = .003), tumor location according to the hepatic lobe (P < .001), type of hepatectomy (P < .001), adjuvant treatment (P < .001), and postoperative complications (P = .028). Tumor recurrence at a distant site was observed in 102 patients (68.5%). LN metastasis was independently associated with risk of distant recurrence (P = .002). The LN (D) and LN (D0) groups did not differ in overall survival (P = .101) or disease-free survival (P = .111). Poorly differentiated histologic grade (P = .016) and LN metastasis (P < .001) was identified as an independent predictor of overall survival. CONCLUSION: Routine LND for ICC did not show survival benefits; however, LN sampling might be useful for nodal staging, an essential factor in predicting outcome and deciding whether to apply adjuvant treatment.
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Authors | Dong Hun Kim, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo, Alfred Wei-Chieh Kow |
Journal | Surgery
(Surgery)
Vol. 157
Issue 4
Pg. 666-75
(Apr 2015)
ISSN: 1532-7361 [Electronic] United States |
PMID | 25682172
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Bile Duct Neoplasms
(mortality, pathology, surgery)
- Bile Ducts, Intrahepatic
(pathology, surgery)
- Cholangiocarcinoma
(mortality, pathology, surgery)
- Female
- Hepatectomy
- Humans
- Liver
(pathology, surgery)
- Lymph Node Excision
(methods)
- Lymphatic Metastasis
- Male
- Middle Aged
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
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