[Comparison of diagnostic performance of two tests of premature rupture of membranes (IGFBP-1/PAMG-1) in clinical practice].

Abstract

OBJECTIVES:

Evaluate the two main immunochromatographic tests of premature rupture of membranes (PROM): Actimprom(®) based on the discovery of insulin-like growth factor binding protein-1 (IGFBP-1) and Amnisure(®) based on the discovery of placental alpha 1-microglobulin (PAMG -1). The comparison was made voluntarily in clinical practice and is interested in a population whose failure is not clean break.

MATERIALS AND METHODS:

Prospective and comparative study performed on 2012, at the university hospital of Caen, in 85 patients with PROM suspected between 24 SA and 36 SA. The presence of blood, semen or vaginal infection has been notified. Frank rupture of membranes was an exclusion criterion.

RESULTS:

Actimprom(®) and Amnisure(®) were detected PROM with a specificity, sensitivity, PPV and NPV respectively 89.4% (CI 79.4-95.6%), 68.4% (CI 43.5-87.4%), 65% (CI 40.8-84.6%) and 90.8% (CI 81-96.5%). The results of both tests were not influenced by the presence of blood or inflammatory disease.

CONCLUSION:

Performance of these tests is probably related to the quality of the sample and the extraction step in bed of the patient. This work showed no significant difference between the two tests in terms of performance in the diagnosis of PROM. At present, there is no formally favor the use of one or the other.

• Authors: M Lecerf, D Vardon, R Morello, N Lamendour, M Dreyfus
• Journal: Journal de gynecologie, obstetrique et biologie de la reproduction (J Gynecol Obstet Biol Reprod (Paris)) Vol. 44 Issue 9 Pg. 832-9 (Nov 2015) ISSN: 1773-0430 [Electronic] France
• Vernacular Title: Comparaison des performances diagnostiques de deux tests de rupture prématurée des membranes (IGFBP-1/PAMG-1) en pratique clinique.
• PMID: 25638475 (Publication Type: Comparative Study, English Abstract, Journal Article, Observational Study)
• Copyright: Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Chemical References

• IGFBP1 protein, human
• Insulin-Like Growth Factor Binding Protein 1

Topics

• Adult
• Amniotic Fluid (chemistry)
• Female
• Fetal Membranes, Premature Rupture (diagnosis)
• Humans
• Insulin-Like Growth Factor Binding Protein 1 (analysis)
• Predictive Value of Tests
• Pregnancy
• Prospective Studies