Abstract | BACKGROUND: OBJECTIVES: METHODS: Baseline HDL particle number was measured using nuclear magnetic resonance spectroscopy in 930 participants ages 45 to 74 years in a community-based cohort study. An estimate of cholesterol molecules per HDL particle (HDL-C/P ratio) was calculated as the ratio of HDL cholesterol to HDL particles. HDL-C/P ratio was categorized as <41.0 (lowest), 41.0 to 46.9, 47.0 to 52.9, and ≥53.0 (highest) using a fixed increment method. Modified Poisson regression was used to assess the association between HDL-C/P ratio and 5-year progression of carotid atherosclerosis as indicated by progression of carotid plaques and change in total plaque area (TPA). RESULTS: Mean baseline HDL-C/P ratio was 46.4 ± 9.3 (range 23.8 to 86.9). Baseline HDL-C/P ratio was significantly associated with 5-year progression of carotid atherosclerosis. Participants with the highest HDL-C/P ratio had 1.56-fold (95% confidence interval: 1.14 to 2.13; p = 0.006) increased progression compared with those with the lowest level. Among participants without baseline plaque, TPA in re-examination was larger by 9.4 mm(2) in the subgroup with the highest level when compared with the lowest level. CONCLUSIONS: Our findings suggest that cholesterol-overloaded HDL particles are independently associated with the progression of carotid atherosclerosis. This may explain why in recent trials raising HDL cholesterol was not beneficial. This study strongly suggests that the combination of cholesterol content and particle number determines the antiatherogenic function of HDLs, rather than either parameter alone.
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Authors | Yue Qi, Jie Fan, Jing Liu, Wei Wang, Miao Wang, Jiayi Sun, Jun Liu, Wuxiang Xie, Fan Zhao, Yan Li, Dong Zhao |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 65
Issue 4
Pg. 355-363
(Feb 03 2015)
ISSN: 1558-3597 [Electronic] United States |
PMID | 25634834
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Carotid Artery Diseases
(blood, diagnostic imaging)
- Cholesterol, HDL
(blood, chemistry)
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Ultrasonography
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