Enhancing transungual delivery and spreading of efinaconazole under the nail plate through a unique formulation approach.

Abstract

Onychomycosis is a very common nail disorder seen in dermatological practice. It is difficult to treat successfully for a multitude of reasons, and although topical antifungal therapy might be considered ideal for mild to moderate onychomycosis, efficacy has been limited by poor nail penetration of active ingredient through the nail plate into the nail bed and nail matrix to the site of infection. The intrinsic properties of an antifungal and its vehicle formulation are both considered important contributors to effective treatment. Here we review the formulation approach to efinaconazole topical solution, 10% an effective and well-tolerated treatment for onychomycosis. We demonstrate that the low surface tension formulation affords better penetration of efinaconazole through the nail plate, and also to the site of infection by spreading into the space between the nail and nail bed.

• Authors: Leon H Kircik
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 13 Issue 12 Pg. 1457-61 (Dec 2014) ISSN: 1545-9616 [Print] United States
• PMID: 25607788 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antifungal Agents
• Triazoles
• efinaconazole

Topics

• Administration, Topical
• Antifungal Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Chemistry, Pharmaceutical
• Drug Delivery Systems
• Humans
• Nails (metabolism, microbiology)
• Onychomycosis (drug therapy)
• Permeability
• Triazoles (administration & dosage, pharmacokinetics, therapeutic use)