Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report.

Abstract

BACKGROUND:

Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.

METHODS:

GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model.

RESULTS:

GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism.

CONCLUSION:

The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.

• Authors: Jonai Pujol-Gimenez, Fátima Pérez de Heredia, Miguel Angel Idoate, Rachel Airley, María Pilar Lostao, Andrew Robert Evans
• Journal: Journal of Cancer (J Cancer) Vol. 6 Issue 2 Pg. 139-43 ( 2015) ISSN: 1837-9664 [Print] Australia
• PMID: 25561978 (Publication Type: Journal Article)