Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells.

Abstract

BACKGROUND/AIM:

Cancer stem cells (CSCs) are considered to contribute to the poor prognosis of ovarian cancer as a major cause of fatal recurrence. Identification of effective measures to eliminate ovarian CSCs through induction of cell death and/or loss of self-renewal capacity would, therefore, be key to successful management of ovarian cancer.

MATERIALS AND METHODS:

The effects of resveratrol on the viability and self-renewal capacity of CSCs derived from A2780 human ovarian cancer cells were examined. The involvement of reactive oxygen species (ROS) was also investigated.

RESULTS:

At a non-toxic to normal human fibroblasts concentration, resveratrol effectively killed ovarian CSCs independently of ROS, while ROS-dependently impaired the self-renewal capacity of ovarian CSCs that survived resveratrol treatment.

CONCLUSION:

Our findings not only shed light on a novel mechanism of action for resveratrol but also suggest that resveratrol, or its analogs, may be useful for CSC-directed therapy against ovarian cancer.

• Authors: Manabu Seino, Masashi Okada, Keita Shibuya, Shizuka Seino, Shuhei Suzuki, Hiroyuki Takeda, Tsuyoshi Ohta, Hirohisa Kurachi, Chifumi Kitanaka
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 1 Pg. 85-96 (Jan 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 25550538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Reactive Oxygen Species
• Stilbenes
• Resveratrol

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Drug Screening Assays, Antitumor
• Female
• Humans
• Neoplastic Stem Cells (drug effects, physiology)
• Ovarian Neoplasms
• Oxidative Stress
• Reactive Oxygen Species (metabolism)
• Resveratrol
• Stilbenes (pharmacology)