Abstract | OBJECTIVE: METHODS: Patients admitted with a diagnosis of ICH were prospectively included and divided into 3 groups based on their genetically determined Hp phenotype: 1-1, 2-1, and 2-2. Outcome measures included mortality and 30-day modified Rankin Scale scores. Demographics and outcomes were compared for each phenotype using multivariate linear regression analysis. RESULTS: The study included 94 patients. The distribution of Hp phenotype was Hp 1-1, 12 (13%); Hp 2-1, 46 (49%); and Hp 2-2, 36 (38%). The 3 Hp subgroups did not differ in terms of demographic variables, comorbidities, or ICH characteristics. There was a nonsignificant trend toward increased mortality in Hp 2-1 and Hp 2-2 compared with Hp 1-1, with mortality of 8% in Hp 1-1, 17% in Hp 2-1, and 25% in Hp 2-2 (P = 0.408). In the regression model adjusted for confounders, Hp 2-1 (odds ratio = 0.05, 95% confidence interval = 0.01-0.47, P < 0.001) and Hp 2-2 phenotypes (odds ratio = 0.14, 95% confidence interval = 0.02-0.86, P = 0.045) had significantly lower odds of modified Rankin Scale scores 0-2 compared with Hp 1-1. CONCLUSIONS: After ICH, individuals with the Hp-2 allele (2-1 and 2-2) had worse functional outcomes than individuals with the Hp-1 allele (Hp 1-1). There was a nonsignificant association between Hp phenotype and mortality. Larger prospective studies with better surrogates of ICH outcomes are warranted.
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Authors | Santosh B Murthy, Andrew P Levy, Joshua Duckworth, Eric B Schneider, Hadar Shalom, Daniel F Hanley, Rafael J Tamargo, Paul A Nyquist |
Journal | World neurosurgery
(World Neurosurg)
Vol. 83
Issue 4
Pg. 583-7
(Apr 2015)
ISSN: 1878-8769 [Electronic] United States |
PMID | 25527876
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Alleles
- Cohort Studies
- Female
- Glasgow Coma Scale
- Haptoglobins
(genetics)
- Humans
- Hypertension
(complications, genetics)
- Intracranial Hemorrhages
(genetics, mortality, therapy)
- Male
- Middle Aged
- Phenotype
- Prospective Studies
- Risk Factors
- Subarachnoid Hemorrhage
(genetics, mortality, therapy)
- Treatment Outcome
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