Histamine-releasing factor/translationally controlled tumor protein plays a role in induced cell adhesion, apoptosis resistance and chemoresistance in non-Hodgkin lymphomas.
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| Abstract |
Mounting evidence has proved that cellular adhesion confers resistance to chemotherapy in multiple lymphomas. The molecular mechanism underlying cell adhesion-mediated drug resistance (CAM-DR) is, however, poorly understood. In this study, we investigated the expression and biologic function of histamine-releasing factor (HRF) in non-Hodgkin lymphomas (NHLs). Clinically, by immunohistochemistry analysis we observed obvious up-regulation of HRF in NHLs including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and natural killer (NK)/T-cell lymphoma. Functionally, overexpression and knockdown of HRF demonstrated the antiapoptotic effect of HRF in NHL cells, which may be associated with activation of the p-CREB/BCL-2 signaling pathway. Moreover, cell adhesion assay demonstrated that adhesion to fibronectin (FN) or HS-5 up-regulated HRF expression, while knockdown of HRF resulted in decreased cell adhesion, which led to reversed CAM-DR. Our finding supports the role of HRF in NHL cell apoptosis, adhesion and drug resistance, and may provide a clinical therapeutic target for CAM-DR in NHL.
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| Authors | Song He, Yuejiao Huang, Yuchan Wang, Jie Tang, Yan Song, Xiafei Yu, Jing Ma, Shitao Wang, Haibing Yin, Qiuyue Li, Lili Ji, Xiaohong Xu |
| Journal | Leukemia & lymphoma (Leuk Lymphoma) Vol. 56 Issue 7 Pg. 2153-61 (Jul 2015) ISSN: 1029-2403 [Electronic] United States |
| PMID | 25363345 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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