Abstract | PURPOSE: METHODS: 42 patients undergoing vv-ECMO between 1998 and 2009 were identified. In 20 out of these patients, a polypropylene (PP) microporous hollow fiber membrane oxygenator, and in 22 patients a nonmicroporous polymethylpentene (PMP) diffusion membrane oxygenator was used. Infection incidence, changing frequency, and mortality were documented. RESULTS: In the PMP group, an oxygenator change was necessary less often than in the PP group (p<0.001). The incidence of bacterial, viral, or fungal growth was similar in the groups, thus independent of the frequency of oxygenator change. Irrespective of the groups, the occurrence of Candida sp. tended to correlate with death (p = 0.06). In general, there was a trend towards a higher infection incidence in the subgroup with pulmonary ARDS (p = 0.07). Moreover, infection incidence was associated with a longer ICU stay (p = 0.03) and longer ECMO therapy (p = 0.03). ICU mortality was lower in the PMP group than in the PP group, although not statistically significant (p = 0.10). CONCLUSIONS: The PMP oxygenator membranes showed benefits with regards to changing frequency, but not infection incidence, length of ICU stay, and length of ECMO therapy. There was a trend towards a lower ICU mortality in patients with PMP oxygenators.
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Authors | Oliver Robak, Philipp K S Lakatos, Andja Bojic, Alexander Hermann, Klaus-Felix Laczika, Astrid Chiari, Jörg M Hiesmayr, Thomas Staudinger, Gottfried J Locker |
Journal | The International journal of artificial organs
(Int J Artif Organs)
Vol. 37
Issue 11
Pg. 839-46
(Nov 2014)
ISSN: 1724-6040 [Electronic] United States |
PMID | 25362902
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Polyenes
- Polypropylenes
- poly(methylpentene)
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Topics |
- Adult
- Bacterial Infections
(diagnosis, microbiology, mortality)
- Communicable Diseases
(diagnosis, etiology, mortality)
- Equipment Contamination
- Equipment Design
- Extracorporeal Membrane Oxygenation
(adverse effects, instrumentation, mortality)
- Female
- Humans
- Incidence
- Infection Control
- Male
- Middle Aged
- Mycoses
(diagnosis, microbiology, mortality)
- Oxygenators, Membrane
(adverse effects)
- Polyenes
- Polypropylenes
- Porosity
- Respiratory Distress Syndrome
(diagnosis, mortality, therapy)
- Retrospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Virus Diseases
(diagnosis, mortality, virology)
- Young Adult
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