[Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases].

Abstract

We evaluated the significance of indoleamine 2,3-dioxygenase(IDO)activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine(Trp/Kyn)ratio. Trp and Kyn were measured by high-performance liquid chromatography(HPLC). The survival rate after recurrence was higher in the local recurrence group(n=11)than in the distant metastases group(n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.

• Authors: Kenichi Sakurai, Shigeru Fujisaki, Shuhei Suzuki, Saki Nagashima, Tetsuyo Maeda, Ryouichi Tomita, Yukiko Hara, Tomohiro Hirano, Katsuhisa Enomoto, Sadao Amano
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 10 Pg. 1304-6 (Oct 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 25335725 (Publication Type: English Abstract, Journal Article)

Chemical References

• Indoleamine-Pyrrole 2,3,-Dioxygenase
• Kynurenine
• Tryptophan

Topics

• Adult
• Aged
• Breast Neoplasms (blood, enzymology, pathology)
• Female
• Humans
• Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism)
• Kynurenine (blood)
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (blood, enzymology)
• Tryptophan (blood)