Enhanced down-regulation of ALCAM/CD166 in African-American Breast Cancer.
Abstract | BACKGROUND: METHODS: RESULTS: Univariate analysis revealed that the level of ALCAM expression at intercellular junctions of primary tumors correlates with histological grade (AA; p = 0.04, CUA; p = 0.02), ER status (AA; p = 0.0004, CAU; p = 0.0015), PR status (AA; p = 0.002, CUA p = 0.034) and triple-negative tumor status (AA; p = 0.0002, CAU; p = 0.0006,) in both ethnic groups. Multivariate analysis demonstrated that ethnicity contribute significantly to ALCAM expression after accounting for basal-like subtype, age, histological grade, tumor size, and lymph node status. Compared to CAU tumors, the AA are 4 times more likely to have low ALCAM expression (p = 0.003). CONCLUSIONS: Markedly low expression of ALCAM at sites of cell-cell contact in primary breast cancer tumors regardless of differentiation, size and lymph node involvement may contribute to the more aggressive phenotype of breast cancer among AA women.
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Authors | Fang Tan, Marina Mosunjac, Amy L Adams, Beverly Adade, Oleyad Taye, Yijuan Hu, Monica Rizzo, Solomon F Ofori-Acquah |
Journal | BMC cancer
(BMC Cancer)
Vol. 14
Pg. 715
(Sep 25 2014)
ISSN: 1471-2407 [Electronic] England |
PMID | 25255861
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- ALCAM protein, human
- Antigens, CD
- Cell Adhesion Molecules, Neuronal
- Fetal Proteins
- Receptors, Estrogen
- Receptors, Progesterone
- ERBB2 protein, human
- Receptor, ErbB-2
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Topics |
- Black or African American
- Antigens, CD
(genetics, metabolism)
- Breast Neoplasms
(ethnology, metabolism, pathology)
- Carcinoma, Ductal, Breast
(ethnology, metabolism, secondary)
- Cell Adhesion Molecules, Neuronal
(genetics, metabolism)
- Down-Regulation
- Female
- Fetal Proteins
(genetics, metabolism)
- Gene Expression
- Humans
- Lymphatic Metastasis
- Middle Aged
- Phenotype
- Receptor, ErbB-2
(metabolism)
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
- Tumor Burden
- White People
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