Prognostic value of elevated serum ceruloplasmin levels in patients with heart failure.

Abstract

BACKGROUND:

Ceruloplasmin (Cp) is a copper-binding acute-phase protein that is increased in inflammatory states and deficient in Wilson's disease. Recent studies demonstrate that increased levels of Cp are associated with increased risk of developing heart failure. Our objective was to test the hypothesis that serum Cp provides incremental and independent prediction of survival in stable patients with heart failure.

METHODS AND RESULTS:

We measured serum Cp levels in 890 patients with stable heart failure undergoing elective cardiac evaluation that included coronary angiography. We examined the role of Cp levels in predicting survival over 5 years of follow-up. Mean Cp level was 26.6 ± 6.9 mg/dL and demonstrated relatively weak correlation with B-type natriuretic peptide (BNP; r = 0.187; P < .001). Increased Cp levels were associated with increased 5-year all-cause mortality (quartile [Q] 4 vs Q1 hazard ratio [HR] 1.9, 95% confidence interval [CI] 1.4-2.8; P < .001). When controlled for coronary disease traditional risk factors, creatinine clearance, dialysis, body mass index, medications, history of myocardial infarction, BNP, left ventricular ejection fraction (LVEF), heart rate, QRS duration, left bundle branch blockage, and implantable cardioverter-defibrillator placement, higher Cp remained an independent predictor of increased mortality (Q4 vs Q1 HR 1.7, 95% CI 1.1-2.6; P < .05). Model quality was improved with addition of Cp to the aforementioned covariables (net reclassification improvement of 9.3%; P < .001).

CONCLUSIONS:

Ceruloplasmin is an independent predictor of all-cause mortality in patients with heart failure. Measurement of Cp may help to identify patients at heightened mortality risk.

• Authors: Muhammad Hammadah, Yiying Fan, Yuping Wu, Stanley L Hazen, W H Wilson Tang
• Journal: Journal of cardiac failure (J Card Fail) Vol. 20 Issue 12 Pg. 946-52 (Dec 2014) ISSN: 1532-8414 [Electronic] United States
• PMID: 25128745 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Natriuretic Peptide, Brain
• Ceruloplasmin

Topics

• Academic Medical Centers
• Aged
• Biomarkers (blood)
• Cardiac Catheterization
• Ceruloplasmin (analysis, metabolism)
• Cohort Studies
• Confidence Intervals
• Disease Progression
• Disease-Free Survival
• Female
• Heart Failure (blood, mortality, physiopathology)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Monitoring, Physiologic (methods)
• Natriuretic Peptide, Brain (blood)
• Ohio
• Predictive Value of Tests
• Prognosis
• Proportional Hazards Models
• ROC Curve
• Retrospective Studies
• Survival Analysis