The expression of δ-catenin in esophageal squamous cell carcinoma and its correlations with prognosis of patients.

Abstract

As a member of the catenin family, expression of δ-catenin and its clinical implication in numerous tumors remain unclear. In the present study, expression of δ-catenin in esophageal squamous cell carcinoma (ESCC) and its correlations with patient prognosis were explored. We detected the expression of δ-catenin, by immunohistochemistry, in ESCC tissues from 299 cases and analyzed the correlation between δ-catenin expression and patient clinicopathological features. Compared with a lack of expression in adjacent normal esophageal epithelium (0%, 0/47), the frequency of δ-catenin protein was increased in ESCC tissues to 41.5% (124/299, P < .001) and expression correlated with TNM stage and lymph node metastasis (P = .025 and .019, respectively). Furthermore, Kaplan-Meier survival analysis revealed that patients with high δ-catenin expression had shorter survival than patients with low expression (P = .010), and multivariate Cox analysis revealed that high δ-catenin expression was also an independent prognostic factor (P = .001). In transwell assays, migration of ESCC cells was enhanced by δ-catenin overexpression, whereas proliferation of ESCC cells was unchanged. Together, our results suggest that δ-catenin acts as an oncoprotein when overexpressed in ESCC, and its expression is associated with poor prognosis and malignant cell behavior.

• Authors: Jun-Yi Zhang, Chun-Ying Bai, Yu-Qin Bai, Jing-Yi Zhang, Zhi-Yong Wu, Shao-Hong Wang, Xiu-E Xu, Jian-Yi Wu, Ying Zhu, Yun Rui, En-Min Li, Li-Yan Xu
• Journal: Human pathology (Hum Pathol) Vol. 45 Issue 10 Pg. 2014-22 (Oct 2014) ISSN: 1532-8392 [Electronic] United States
• PMID: 25090917 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Catenins
• Delta Catenin

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis, metabolism)
• Blotting, Western
• Carcinoma, Squamous Cell (metabolism, mortality, pathology)
• Catenins (biosynthesis)
• Esophageal Neoplasms (metabolism, mortality, pathology)
• Esophageal Squamous Cell Carcinoma
• Female
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Real-Time Polymerase Chain Reaction
• Tissue Array Analysis
• Delta Catenin