Randomised in situ trial on the effect of milk and CPP-ACP on dental erosion.

Abstract

OBJECTIVES:

This randomised in situ study aimed to analyse the effect of milk (with or without 5ppm F) and CPP-ACP pastes (with or without 900ppm F) on dental erosion.

METHODS:

The study was a seven phase (5 days each) crossover design involving 15 participants wearing intraoral appliances with enamel and dentine specimens. Specimens were extraorally eroded (erosive soft drink, 6×90s/day) and brushed (2×30s/day, 2N) using a non-fluoridated toothpaste (negative control). The test products were milk, milk+5ppm F (twice daily, each 100ml/2min), CPP-ACP paste, CPP-ACP paste+900ppm F (3min/day) or a SnCl2/AmF/NaF mouthrinse (positive control, 30s/day), which were applied immediately after erosion with the appliances in the oral cavity. In an additional group, a fluoridated toothpaste was used without any additional test product. Tissue loss was determined profilometrically after 5 days and statistically analysed by linear mixed models methodologies (p<0.05).

RESULTS:

Compared with the negative control (non-fluoridated toothpaste only, enamel: 2.2±1.3μm; dentine: 3.8±2.2μm), enamel and dentine loss was significantly reduced by the use of fluoridated toothpaste (enamel: 1.1±1.0μm; dentine: 2.4±1.7μm) and the SnCl2/AmF/NaF mouthrinse (1.5±1.5μm; dentine: 1.8±1.9μm).

CONCLUSIONS:

Milk and CPP-ACP were not effective in reducing enamel and dentine loss significantly, independently of the presence of fluoride.

CLINICAL SIGNIFICANCE:

Enamel and dentine erosion were significantly reduced by the use of a fluoridated toothpaste or a SnCl2/AmF/NaF mouthrinse, but not by milk or CPP-ACP under the conditions of the present study.

CLINICAL TRIALS REGISTRATION:

NCT01566357.

• Authors: Annette Wiegand, Thomas Attin
• Journal: Journal of dentistry (J Dent) Vol. 42 Issue 9 Pg. 1210-5 (Sep 2014) ISSN: 1879-176X [Electronic] England
• PMID: 25038509 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Amines
• Cariostatic Agents
• Caseins
• Mouthwashes
• Tin Compounds
• Toothpastes
• casein phosphopeptide-amorphous calcium phosphate nanocomplex
• stannous chloride
• Sodium Fluoride
• Fluorides

Topics

• Adult
• Amines (therapeutic use)
• Animals
• Cariostatic Agents (therapeutic use)
• Caseins (therapeutic use)
• Cattle
• Cross-Over Studies
• Dental Enamel (drug effects)
• Dentin (drug effects)
• Female
• Fluorides (therapeutic use)
• Humans
• Male
• Milk
• Mouthwashes (therapeutic use)
• Prospective Studies
• Single-Blind Method
• Sodium Fluoride (therapeutic use)
• Tin Compounds (therapeutic use)
• Tooth Abrasion (prevention & control)
• Tooth Erosion (prevention & control)
• Toothpastes (therapeutic use)