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Lung cancer in never-smokers: a case-control study in a radon-prone area (Galicia, Spain).

Abstract
The aim of the study was to assess the effect of residential radon exposure on the risk of lung cancer in never-smokers and to ascertain if environmental tobacco smoke modifies the effect of residential radon. We designed a multicentre hospital-based case-control study in a radon-prone area (Galicia, Spain). All participants were never-smokers. Cases had an anatomopathologically confirmed primary lung cancer and controls were recruited from individuals undergoing minor, non-oncological surgery. Residential radon was measured using alpha track detectors. We included 521 individuals, 192 cases and 329 controls, 21% were males. We observed an odds ratio of 2.42 (95% CI 1.45-4.06) for individuals exposed to ≥200 Bq·m(-3) compared with those exposed to <100 Bq·m(-3). Environmental tobacco smoke exposure at home increased lung cancer risk in individuals with radon exposure>200 Bq·m(-3). Individuals exposed to environmental tobacco smoke and to radon concentrations>200 Bq·m(-3) had higher lung cancer risk than those exposed to lower radon concentrations and exposed to environmental tobacco smoke. Residential radon increases lung cancer risk in never-smokers. An association between residential radon exposure and environmental tobacco smoke on the risk of lung cancer might exist.
AuthorsMaría Torres-Durán, Alberto Ruano-Ravina, Isaura Parente-Lamelas, Virginia Leiro-Fernández, José Abal-Arca, Carmen Montero-Martínez, Carolina Pena-Álvarez, Francisco Javier González-Barcala, Olalla Castro-Añón, Antonio Golpe-Gómez, Cristina Martínez, María José Mejuto-Martí, Alberto Fernández-Villar, Juan Miguel Barros-Dios
JournalThe European respiratory journal (Eur Respir J) Vol. 44 Issue 4 Pg. 994-1001 (Oct 2014) ISSN: 1399-3003 [Electronic] England
PMID25034571 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Copyright©ERS 2014.
Chemical References
  • Tobacco Smoke Pollution
  • Radon
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Housing
  • Humans
  • Lung Neoplasms (chemically induced, epidemiology)
  • Male
  • Middle Aged
  • Radon (adverse effects)
  • Risk Factors
  • Spain
  • Tobacco Smoke Pollution (adverse effects)

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