Lung cancer in never-smokers: a case-control study in a radon-prone area (Galicia, Spain).

The aim of the study was to assess the effect of residential radon exposure on the risk of lung cancer in never-smokers and to ascertain if environmental tobacco smoke modifies the effect of residential radon. We designed a multicentre hospital-based case-control study in a radon-prone area (Galicia, Spain). All participants were never-smokers. Cases had an anatomopathologically confirmed primary lung cancer and controls were recruited from individuals undergoing minor, non-oncological surgery. Residential radon was measured using alpha track detectors. We included 521 individuals, 192 cases and 329 controls, 21% were males. We observed an odds ratio of 2.42 (95% CI 1.45-4.06) for individuals exposed to ≥200 Bq·m(-3) compared with those exposed to <100 Bq·m(-3). Environmental tobacco smoke exposure at home increased lung cancer risk in individuals with radon exposure>200 Bq·m(-3). Individuals exposed to environmental tobacco smoke and to radon concentrations>200 Bq·m(-3) had higher lung cancer risk than those exposed to lower radon concentrations and exposed to environmental tobacco smoke. Residential radon increases lung cancer risk in never-smokers. An association between residential radon exposure and environmental tobacco smoke on the risk of lung cancer might exist.
AuthorsMaría Torres-Durán, Alberto Ruano-Ravina, Isaura Parente-Lamelas, Virginia Leiro-Fernández, José Abal-Arca, Carmen Montero-Martínez, Carolina Pena-Álvarez, Francisco Javier González-Barcala, Olalla Castro-Añón, Antonio Golpe-Gómez, Cristina Martínez, María José Mejuto-Martí, Alberto Fernández-Villar, Juan Miguel Barros-Dios
JournalThe European respiratory journal (Eur Respir J) Vol. 44 Issue 4 Pg. 994-1001 (Oct 2014) ISSN: 1399-3003 [Electronic] England
PMID25034571 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Copyright©ERS 2014.
Chemical References
  • Tobacco Smoke Pollution
  • Radon
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Housing
  • Humans
  • Lung Neoplasms (chemically induced, epidemiology)
  • Male
  • Middle Aged
  • Radon (adverse effects)
  • Risk Factors
  • Spain
  • Tobacco Smoke Pollution (adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: