Abstract | PURPOSES: To evaluate the efficacy of human amniotic membrane (AM) grafting in the canine penile tunica albuginea defect; we developed an animal model as the first step toward an innovating new method for the treatment of Peyronie's disease, penile cancers, and congenital deformities of the penis. MATERIAL AND METHODS: From August to September 2011, ten healthy male dogs were selected. A rhomboid incision about 3 x 2 cm over the tunica albuginea and its overlying squamous epithelium was made and then excised. The amniotic membrane was folded twice on itself and grafted on the defect. After 8 weeks, artificial erection was made for 5 dogs and for the other 5 dogs after 12 weeks. After artificial erection, partial penectomy was done and histopathological evaluation was performed on the grafts. RESULTS: Artificial erection performed successfully in all of the dogs. No infection or any other complication was seen. Histopathological examination showed complete re-epithelialization with squamous epithelium and collagen fiber deposition. Also, no dysplasia was seen. CONCLUSIONS: The amniotic membrane can be used as a suitable substitution for tunica albuginea. It is safe, inexpensive, biodegradable, and available and may be used for the treatment of Peyronie ' s disease, penile cancers, congenital penile deformities, and penile reconstructive surgery.
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Authors | M Salehipour, K Izadpanah, A Safaei, M Kamranpoor, M R Farsiani |
Journal | International braz j urol : official journal of the Brazilian Society of Urology
(Int Braz J Urol)
Vol. 40
Issue 3
Pg. 400-7
( 2014)
ISSN: 1677-6119 [Electronic] Brazil |
PMID | 25010307
(Publication Type: Evaluation Study, Journal Article)
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Topics |
- Absorbable Implants
- Amnion
(transplantation)
- Animals
- Dogs
- Humans
- Male
- Models, Animal
- Penile Induration
(pathology, surgery)
- Penile Neoplasms
(surgery)
- Penis
(abnormalities, pathology, surgery)
- Reproducibility of Results
- Time Factors
- Treatment Outcome
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