Serglycin expression: An independent marker of distant metastases in nasopharyngeal carcinoma.

Abstract

BACKGROUND:

Nasopharyngeal carcinoma (NPC) has a high propensity for metastasis. The purpose of this study was for us to determine whether serglycin expression can be used to predict distant metastases.

METHODS:

Serglycin expression of tumor tissue of 112 patients with NPC was assessed based on percentage of tumor cells expressing serglycin, staining intensity, percentage of tumor-infiltrated lymphocyte (TIL) expressing serglycin and TIL-staining intensity.

RESULTS:

Risk factors for distant metastases include sex, smoking status, tumor intensity, and TIL percentage for serglycin. The odds of distant metastases was 4.13 and 0.18 in patients with strong tumor intensity and >50% TIL percentage, respectively. Based on a nomogram incorporating predictors, patients were stratified into 2 prognostic groups. The proportion of distant metastases in the high-risk group (strong tumor intensity and ≤50% TIL percentage) was 78% versus 19% in the low risk group (p < .001).

CONCLUSION:

Patients with NPC with tumors showing strong tumor intensity and low TIL percentage with serglycin may be at high risk for distant metastases.

• Authors: Claramae Shulyn Chia, Whee Sze Ong, Xin Jian Li, Yoke-Lim Soong, Fui Teen Chong, Hiang-Khoon Tan, Khee-Chee Soo, Chao-Nan Qian, Bin-Tean Teh, N Gopalakrishna Iyer
• Journal: Head & neck (Head Neck) Vol. 38 Issue 1 Pg. 21-8 (Jan 2016) ISSN: 1097-0347 [Electronic] United States
• PMID: 24995621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Wiley Periodicals, Inc.

Chemical References

• Biomarkers, Tumor
• Proteoglycans
• Vesicular Transport Proteins
• serglycin

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Carcinoma
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nasopharyngeal Carcinoma
• Nasopharyngeal Neoplasms (diagnosis, genetics, metabolism)
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Proteoglycans (metabolism)
• Risk Factors
• Sensitivity and Specificity
• Severity of Illness Index
• Vesicular Transport Proteins (metabolism)