Prognosis and prognostic factors of differentiated thyroid carcinoma after the appearance of metastasis refractory to radioactive iodine therapy.
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| Abstract |
Differentiated thyroid carcinomas (DTCs) are generally indolent, but few therapeutic strategies are available after a metastatic recurrence that is refractory to radioactive iodine (RAI) therapy. Molecular-target therapy has shown promising results for DTCs with RAI-refractory recurrence. However, not all RAI-refractory recurrences are progressive, and even those that are progressive may not be immediately life-threatening. Here we investigated the prognosis and prognostic factors of 74 DTC patients (52 females, 22 males) in whom RAI-refractory metastases appeared. The five-year and 10-year cause-specific survival (CSS) rates of the 74 patients (8-82 yrs of age; median age at the detection of metastases, 61 yrs) were 95% and 70%, respectively, and the older patients (≥ 60 yrs, n=38) and male patients were significantly more likely to die of carcinoma. Also in multivariate analysis, older age (≥ 60 years) and male gender were independent predictors of carcinoma-related death. Taken together, our data indicate that RAI-refractory metastases of older patients and male patients are more progressive than those of other patients. Further studies are necessary to clarify the appropriate indications for molecular-target therapy for RAI-refractory and progressive metastases.
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| Authors | Yasuhiro Ito, Akira Miyauchi, Mitsuru Ito, Tomonori Yabuta, Hiroo Masuoka, Takuya Higashiyama, Mitsuhiro Fukushima, Kaoru Kobayashi, Minoru Kihara, Akihiro Miya |
| Journal | Endocrine journal (Endocr J) Vol. 61 Issue 8 Pg. 821-4 ( 2014) ISSN: 1348-4540 [Electronic] Japan |
| PMID | 24871888 (Publication Type: Journal Article) |
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