Abstract | OBJECTIVE: DESIGN: Two prospective cohort studies (Nurses' Health Study and Nurses' Health Study II). SETTING: Not applicable. PATIENT(S): A cohort of 121,700 married US female nurses, aged 30-55 years at baseline and another cohort of 116,430 US female nurses aged 25-42 years at baseline. INTERVENTION(S): MAIN OUTCOME MEASURE(S): RESULT(S): Overall, tubal ligation was associated with a decreased risk of ovarian cancer (HR, 0.76; 95% CI 0.64-0.90). The inverse association was stronger for nonserous tumors (HR, 0.57; 95% CI 0.40-0.82) and among women younger than 35 years at surgery (HR, 0.67; 95% CI 0.49-0.90). Hysterectomy was associated with a decreased risk of ovarian cancer (HR, 0.80; 95% CI 0.66-0.97) and was somewhat stronger for nonserous tumors (HR, 0.70; 95% CI 0.49-1.02). Unilateral oophorectomy was associated with a 30% lower risk (HR, 0.70; 95% CI 0.53-0.91), which did not differ by histologic subtype. CONCLUSION(S):
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Authors | Megan S Rice, Susan E Hankinson, Shelley S Tworoger |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 102
Issue 1
Pg. 192-198.e3
(Jul 2014)
ISSN: 1556-5653 [Electronic] United States |
PMID | 24825424
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Age Factors
- Carcinoma, Ovarian Epithelial
- Female
- Health Surveys
- Humans
- Hysterectomy
- Incidence
- Middle Aged
- Neoplasms, Glandular and Epithelial
(epidemiology, pathology, prevention & control)
- Nurses
- Ovarian Neoplasms
(epidemiology, pathology, prevention & control)
- Ovariectomy
- Prospective Studies
- Risk Factors
- Sterilization, Tubal
- Surveys and Questionnaires
- Time Factors
- United States
(epidemiology)
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