Graft and viral outcomes in retransplantation for hepatitis C virus recurrence and HCV primary liver transplantation: a case-control study.

Abstract

INTRODUCTION:

The use of liver retransplantation (ReLT) for hepatitis C virus (HCV) recurrence is controversial because of subsequent viral recurrence after ReLT.

METHODS:

Case-control analysis between patients undergoing ReLT for HCV reinfection between 1993 and 2012 (ReLT group: 26 patients) and patients undergoing liver transplantation (LT) for HCV infection immediately before and after each ReLT (LT group: 52 patients).

RESULTS:

ReLT group had worse hepatocellular function, higher preoperative viral load, higher transfusion requirements, and increased number of postoperative complications than LT group. ReLT patients showed a trend toward worse graft survival compared with LT (five-yr graft survival: 42.3% vs. 64.3%, p = 0.145), but the rate of severe HCV recurrence and infection-free survival (IFS) was similar. The use of donors older than 60 yr led to a lower IFS and graft survival in both groups. Early severe HCV infection rate was similar in both groups, but it affected prognosis in ReLT more markedly than in LT (three-yr graft survival: 0% vs. 66.7%, p = 0.003).

CONCLUSIONS:

ReLT for HCV reinfection has acceptable results when strict selection policies of donor and recipient are applied. However, early severe recurrence more markedly impairs prognosis in ReLT patients than in LT.

• Authors: Josep Martí, Sofia De la Serna, Gonzalo Crespo, Xavier Forns, Joana Ferrer, Constantino Fondevila, Miquel Navasa, Josep Fuster, Juan Carlos García-Valdecasas
• Journal: Clinical transplantation (Clin Transplant) Vol. 28 Issue 7 Pg. 821-8 (Jul 2014) ISSN: 1399-0012 [Electronic] Denmark
• PMID: 24806099 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Topics

• Case-Control Studies
• Disease-Free Survival
• Female
• Follow-Up Studies
• Graft Survival (physiology)
• Hepacivirus (physiology)
• Hepatitis C (diagnosis, physiopathology, surgery, virology)
• Humans
• Liver (physiopathology)
• Liver Transplantation
• Male
• Middle Aged
• Postoperative Complications
• Prognosis
• Recurrence
• Reoperation
• Retrospective Studies
• Risk Factors