[Experimental technology of chemoperfusion treatment for abdominal carcinomatosis in ovarian cancer].

Abstract

An experimental technology of normothermic intraperitoneal chemoperfusion and hyperthermic intraperitoneal chemoperfusion with cisplatin and dioxadet has been elaborated to treat abdominal carcinomatosis in ovarian cancer. Antitumor effects of the treatment were evaluated for the duration of animal life. Normothermic intraperitoneal chemoperfusion and hyperthermic intraperitoneal chemoperfusion with cisplatin and dioxadet in comparison with the standard intraperitoneal administration significantly increased the median life expectancy by 75-92%. Hyperthermic intraperitoneal chemoperfusion with dioxadet demonstrated potentiation of antitumor effect of hyperthermia and dioxadet. Experimental technology is recommended for testing new drugs and methods of chemoperfusion for malignant tumors affecting the peritoneum.

• Authors: O A Beliaeva, V G Bespalov, K Iu Senchik, G S Kireeva, A N Stukov, V A Aristova, A O Ivantsov, E A Vyshinskaia, M A Maĭdin, A L Semënov, V A Aleksandrov, A M Beliaev
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 60 Issue 1 Pg. 71-9 ( 2014) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 24772620 (Publication Type: English Abstract, Journal Article)

Chemical References

• Triazines
• dioxadet
• Cisplatin

Topics

• Abdominal Neoplasms (drug therapy, secondary)
• Animals
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Carcinoma (drug therapy, secondary)
• Chemotherapy, Cancer, Regional Perfusion (instrumentation, methods)
• Cisplatin (administration & dosage)
• Female
• Hyperthermia, Induced
• Neoplasms, Experimental (drug therapy)
• Ovarian Neoplasms (drug therapy, pathology)
• Pelvis
• Rats
• Rats, Wistar
• Triazines (administration & dosage)