The aim of the study was to assess the
propolis effect on
fibronectin metabolism in the course of
burn wounds healing process. A model of
burn wound healing of pig skin was applied. The amount of the released
glycoprotein was assessed by a surface plasmon resonance. The profile of extracted
fibronectin components was also assessed by an electrophoresis in
polyacrylamide gel, with a subsequent immunodetection by Western Blotting.
Propolis burn treatment decreased the release of
fibronectin components from healing
wounds in relation to damages treated with
silver sulfadiazine. The main reason of decreased extraction of
fibronectin components from
wounds treated with
propolis was a substantial decrease of degradation product release of the mentioned
glycoprotein, which was observed particularly from the 3rd to 5th day of the repair.
Wounds treatment with
propolis demonstrated, especially in relation to damages treated with
silver sulfadiazine, the decreased release of synthesized
fibronectin molecules. The obtained results suggest that
propolis modifies
fibronectin metabolism in the course of wound healing process. The influence of
propolis is reflected in prevention of
fibronectin biosynthesis as well as its degradation in the
wound area. The above-mentioned metabolic changes may decrease the risk of complications in the repair
wounds process.