Abstract | OBJECTIVE: METHODS: We searched PubMed, Embase, Wanfang, CNKI data to find relevant randomized controlled trials of noninvasive ventilation for ACPE, which were reported from January 1980 to December 2012. Meta-analysis was performed with software of RevMan 5.1. RESULTS: According to inclusive criteria and exclusion criteria, 35 randomized controlled trials with 3 204 patients were enrolled for analyses. Meta-analysis of the trials showed that continuous positive airway pressure (CPAP) reduced in-hospital mortality by 43% (RR = 0.57, 95%CI 0.43-0.75, P < 0.01) and bilevel positive pressure ventilation (BiPAP) reduced mortality by 31% (RR = 0.69, 95%CI 0.51-0.94, P = 0.02) compared with standard therapy. There were no significant differences in in-hospital mortality between BiPAP and CPAP (RR = 1.09, 95%CI 0.80-1.49, P = 0.57) and myocardial infarction rate (BiPAP vs. CPAP: RR = 1.20, 95%CI 0.95-1.52, P = 0.12; BiPAP vs. standard therapy: RR = 1.10, 95%CI 0.88-1.38, P = 0.40). CONCLUSION:
Noninvasive ventilation (BiPAP and CPAP) could reduce in-hospital mortality of adult patients with ACPE, which could be used as first-line management strategies for these patients.
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Authors | Tongwen Sun, Youdong Wan, Quancheng Kan, Fei Yang, Haimu Yao, Fangxia Guan, Jinying Zhang, Ling Li |
Journal | Zhonghua xin xue guan bing za zhi
(Zhonghua Xin Xue Guan Bing Za Zhi)
Vol. 42
Issue 2
Pg. 161-8
(Feb 2014)
ISSN: 0253-3758 [Print] China |
PMID | 24735630
(Publication Type: English Abstract, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Topics |
- Acute Disease
- Continuous Positive Airway Pressure
- Hospital Mortality
- Humans
- Noninvasive Ventilation
- Pulmonary Edema
(mortality, therapy)
- Randomized Controlled Trials as Topic
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