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Bemiparin, an effective and safe low molecular weight heparin: a review.

Abstract
Bemiparin is a low molecular weight heparin (LMWH) indicated for the acute treatment of deep vein thrombosis with or without pulmonary embolism, for the prophylaxis of venous thromboembolism in surgical and non-surgical patients and for the prevention of clotting in the extracorporeal circuit during hemodialysis. Due to its excellent pharmacological profile-the second-generation LMWH with the lowest molecular weight, the longest half-life and the highest anti-Factor Xa/anti-Factor IIa activity ratio-it can be safely used in special categories of patients (children, elderly, patients with renal impairment and congestive heart failure). Several studies demonstrated its safety and efficacy, while cost analyses show the economic benefits of bemiparin treatment as compared to other heparins. Recent evidences suggested the application of bemiparin even in the management of diabetic foot ulcers. The aim of this narrative review was to evaluate literature according to results coming from studies involving bemiparin administration in various clinical conditions.
AuthorsMarco Matteo Ciccone, Francesca Cortese, Filomena Corbo, Noel Ernesto Corrales, Abdul Kareem Al-Momen, Antonio Silva, Annapaola Zito, Mariangela Pinto, Michele Gesualdo, Pietro Scicchitano
JournalVascular pharmacology (Vascul Pharmacol) Vol. 62 Issue 1 Pg. 32-7 (Jul 2014) ISSN: 1879-3649 [Electronic] United States
PMID24657810 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Anticoagulants
  • Heparin, Low-Molecular-Weight
  • bemiparin
Topics
  • Anticoagulants (adverse effects, economics, pharmacokinetics, therapeutic use)
  • Clinical Trials as Topic
  • Heparin, Low-Molecular-Weight (adverse effects, economics, pharmacokinetics, therapeutic use)
  • Humans
  • Pulmonary Embolism (blood, complications, prevention & control)
  • Treatment Outcome
  • Venous Thrombosis (blood, complications, drug therapy)

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