Effect of low-fat diet on breast cancer survival: a meta-analysis.

Abstract

BACKGROUND:

Even though many studies have examined the possible effect of low-fat diet on breast cancer survival, the relationship remains unclear.

OBJECTIVES:

To summarize the current evidence about the effect of post-diagnostic low-fat diet on recurrence and all-cause mortality of breast cancer.

METHODS:

We conducted a search of Pubmed, Embase, Web of Science, and Cochrane Library and as a result two randomized controlled trials (RCT) and one large multi-center prospective cohort study with 9,966 breast cancer patients were included in this report.

RESULTS:

Post-diagnostic low-fat diet reduced risk of recurrence of breast cancer by 23% (HR=0.77, 95%CI 0.63 to 0.94, P=0.009) and all cause mortality of breast cancer by 17% (HR=0.83, 95%CI 0.69 to 1.00, P=0.05).

CONCLUSIONS:

This meta-analysis suggested the post-diagnostic low-fat diet can improve breast cancer survival by reducing risk of recurrence. However, more trials of the relationship between low-fat diet and all- cause mortality of breast cancer are still needed.

• Authors: Mei-Yuan Xing, Su-Zhen Xu, Peng Shen
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 3 Pg. 1141-4 ( 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 24606431 (Publication Type: Journal Article, Meta-Analysis)

Topics

• Breast Neoplasms (diet therapy, mortality)
• Diet, Fat-Restricted
• Female
• Humans
• Neoplasm Recurrence, Local (diet therapy)
• Treatment Outcome