Abstract | OBJECTIVE: METHODS: We recruited 420 apparently healthy subjects into our I Like HOMe FU study. Among all study participants, we assessed parameters of C1 metabolism ( homocysteine, SAH and S-adenosylmethionine), renal function (estimated glomerular filtration rate [eGFR]) and subclinical atherosclerosis (common carotid intima-media-thickness [IMT]). eGFR was estimated by the CKD-EPIcreat-cys equation. RESULTS: Traditional cardiovascular risk factors and subclinical atherosclerosis were associated with SAH, but not with homocysteine (IMT vs SAH: r = 0.129; p = 0.010; IMT vs homocysteine: r = 0.009; p = 0.853). Moreover, renal function was more closely correlated with SAH than with homocysteine (eGFR vs SAH: r = -0.335; p < 0.001; eGFR vs homocysteine: r = -0.250; p < 0.001). The association between eGFR and SAH remained significant after adjustment for traditional cardiovascular risk factors. CONCLUSION:
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Authors | Adam M Zawada, Kyrill S Rogacev, Björn Hummel, Judith T Berg, Annika Friedrich, Heinz J Roth, Rima Obeid, Jürgen Geisel, Danilo Fliser, Gunnar H Heine |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 234
Issue 1
Pg. 17-22
(May 2014)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 24589563
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Homocysteine
- S-Adenosylmethionine
- S-Adenosylhomocysteine
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Topics |
- Asymptomatic Diseases
- Atherosclerosis
(complications, etiology, metabolism, physiopathology)
- Cardiovascular Diseases
(epidemiology, etiology)
- Female
- Glomerular Filtration Rate
- Homocysteine
(metabolism)
- Humans
- Male
- Middle Aged
- Risk Factors
- S-Adenosylhomocysteine
(metabolism)
- S-Adenosylmethionine
(metabolism)
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