Abstract | OBJECTIVE: BACKGROUND: Despite statin use, residual cardiovascular risk remains. Therapeutic options include more potent statins or addition of ezetimibe. There is no clinical outcome data on the use of ezetimibe in such patients. METHODS: RESULTS: 9597 patients (57% male, mean age of 65 ± 13 years) matched study criteria: simvastatin (n=6990 (72.8%)); high-potency statin (n=1883, (19.6%)); and ezetimibe/ statin combination (n=724 (7.5%)). During a mean follow-up of 3.2 years, there were 1134 (12%) deaths. In the multivariate proportional hazards model, the adjusted HR for high-potency statin and ezetimibe group were 0.72 (95% CI 0.59 to 0.88, p<0.001) and 0.96 (95% CI 0.64 to 1.43, p=0.85), respectively. A similar result was also obtained in the propensity score analysis that took into account covariates that predicted drug treatment groups. CONCLUSIONS: Patients switched to a high-potency statin had a significantly reduced mortality compared with simvastatin monotherapy. There was no observed mortality benefit in the ezetimibe group.
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Authors | Maheshwar Pauriah, Douglas H J Elder, Simon Ogston, Awsan Y S Noman, Azeem Majeed, Jeremy C Wyatt, Anna-Maria Choy, Thomas M Macdonald, Allan D Struthers, Chim C Lang |
Journal | Heart (British Cardiac Society)
(Heart)
Vol. 100
Issue 11
Pg. 867-72
(Jun 2014)
ISSN: 1468-201X [Electronic] England |
PMID | 24553389
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Azetidines
- Drug Combinations
- Ezetimibe, Simvastatin Drug Combination
- Lipids
- Simvastatin
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Topics |
- Aged
- Azetidines
(therapeutic use)
- Drug Combinations
- Drug Therapy, Combination
- Ezetimibe, Simvastatin Drug Combination
- Female
- Follow-Up Studies
- Humans
- Lipids
(blood)
- Male
- Middle Aged
- Myocardial Infarction
(blood, drug therapy, mortality)
- Population Surveillance
- Retrospective Studies
- Simvastatin
(therapeutic use)
- Survival Rate
(trends)
- Survivors
(statistics & numerical data)
- Time Factors
- Treatment Outcome
- United Kingdom
(epidemiology)
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