Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes.

Abstract

BACKGROUND:

The objectives of the study were to compare lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in a prospective cohort including both ischemic and hemorrhagic strokes at the hyperacute phase, and to investigate if these levels were associated with stroke severity.

MATERIALS AND METHODS:

Lp-PLA2 mass and activity were measured during the first 6 hours of symptom onset before any therapeutic intervention. The Lp-PLA2 level was analyzed by comparing the mass and activities in ischemic strokes and spontaneous intracerebral hemorrhages (ICH). Correlations between Lp-PLA2 levels and clinical scores as well as stroke volumes were made. The temporal evolution of Lp-PLA2 during the first week was analyzed in ischemic stroke patients.

RESULTS:

Lp-PLA2 mass was higher in ICH than in ischemic stroke (P = .001). Lp-PLA2 activity at admission correlated with initial and follow-up stroke volume in ICH (P = .003 and P = .004, respectively) but not in ischemic stroke. None of the measurements correlated with clinical severity for either diagnosis. Lp-PLA2 mass decreased during the first week after the use of statins in ischemic stroke, whereas the activity remained stable.

CONCLUSIONS:

Lp-PLA2 mass is higher in ICH compared with ischemic stroke during the hyperacute stage. Lp-PLA2 activity is associated with stroke volume in ICH but not in ischemic stroke. This suggests that Lp-PLA2 mass and activity could provide different information in the hyperacute stage of stroke.

• Authors: Charlotte Rosso, David Rosenbaum, Christine Pires, Corinne Cherfils, Nabil Koujah, Fouzi Mestari, Emeline Gillet, Sophie Crozier, Mélika Sahli-Amor, Yves Samson, Dominique Bonnefont-Rousselot, Randa Khani-Bittar
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 23 Issue 4 Pg. e277-82 (Apr 2014) ISSN: 1532-8511 [Electronic] United States
• PMID: 24513482 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Lipids
• 1-Alkyl-2-acetylglycerophosphocholine Esterase

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (analysis, metabolism)
• Aged
• Aged, 80 and over
• Biomarkers (analysis)
• Brain Ischemia (enzymology)
• Cohort Studies
• Female
• Humans
• Intracranial Hemorrhages (enzymology)
• Lipids (blood)
• Male
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Stroke (enzymology)