Abstract | OBJECTIVE: METHODS: From 2003 to 2011, 305 patients (97 HIV-positive) were diagnosed with DLBCL and treated with R-CHOP. Clinical features were compared using chi-square or Fisher's exact test. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Multivariate analysis was performed using the Cox regression proportional hazards model. RESULTS: HIV-positive patients had more B symptoms and extranodal sites of disease at diagnosis, but the proportion of patients with high-intermediate/high-risk disease according to the international prognostic index (IPI) was similar between groups. Response rate was 73%, both for patients with and without HIV infection. After a median follow-up of 48 months, 30 patients relapsed after achieving a complete remission, including four HIV-positive patients. Ninety-six patients have died (19 HIV-positive), 73 of them due to DLBCL. Three patients (one HIV-positive) died due to treatment toxicity. Patients with HIV infection had a significantly longer disease-free survival (DFS) (5-year: 94 vs. 77%; P = 0.03) and overall survival (OS) (78 and 64% for HIV-positive and HIV-negative patients, respectively; P = 0.03). These results were confirmed on multivariate analysis when controlled for other potential prognostic confounders. CONCLUSION: HIV-positive patients diagnosed with DLBCL in the cART era have an excellent outcome when treated with standard immunochemotherapy. Therefore, the choice of chemotherapy in patients with lymphoma should not be influenced by HIV status.
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Authors | Rita Coutinho, Alessia D Pria, Shreyans Gandhi, Katharine Bailey, Paul Fields, Kate Cwynarski, Andrew Wilson, Panagiotis Papanastasopoulos, Melinda Tenant-Flowers, Andrew Webb, Fiona Burns, Robert E Marcus, Chloe Orkin, Silvia Montoto, Mark Bower |
Journal | AIDS (London, England)
(AIDS)
Vol. 28
Issue 5
Pg. 689-97
(Mar 13 2014)
ISSN: 1473-5571 [Electronic] England |
PMID | 24418826
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal, Murine-Derived
- R-CHOP protocol
- Rituximab
- Vincristine
- Doxorubicin
- Cyclophosphamide
- Prednisone
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal, Murine-Derived
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cyclophosphamide
(therapeutic use)
- Doxorubicin
(therapeutic use)
- Female
- HIV Infections
(complications)
- Humans
- Lymphoma, Large B-Cell, Diffuse
(drug therapy, mortality, pathology)
- Male
- Middle Aged
- Prednisone
(therapeutic use)
- Rituximab
- Survival Analysis
- Treatment Outcome
- Vincristine
(therapeutic use)
- Young Adult
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