A 61-year-old man underwent sigmoidectomy with
partial cystectomy for advanced
sigmoid colon cancer with unresectable multiple liver
metastases at the Okayama University Hospital in June 2006. Pathological examination revealed moderately differentiated
adenocarcinoma, pStage IV( pSI[ bladder], pN0, pH2, pP0, pM0), as per the Japanese Classification of
Colorectal Carcinoma, seventh edition. The patient underwent systematic
chemotherapy with
irinotecan, 5-fluorouraci( l 5-FU), and
folinic acid( FOLFIRI) and
oxaliplatin,
Leucovorin, and 5-FU( mFOLFOX6) for 13 months. In July 2007,
hepatectomy was performed as the liver metastatic lesions had shrunk to a resectable size. Follow-up computed tomography (CT) in November 2009 revealed recurrence in the liver and lung. Subsequently, lateral
segmentectomy was performed for the recurrent liver lesions, and
radiofrequency ablation( RFA) was performed for the lung lesions. After having undergone RFA, the patient is doing well without any re-recurrence. We encountered a patient with advanced
sigmoid colon cancer who was successfully treated with multimodality
therapy. For patients with advanced or recurrent
colorectal cancers, curative resection can lead to a good prognosis; however, in most patients, it is difficult to achieve curative resection by upfront surgery. Multimodality
therapy could facilitate curative resection, thereby resulting in a good prognosis.