Abstract | OBJECTIVE: MATERIALS AND METHODS: Female BALB/c nude mice (aged 5-6 weeks, weighing 18-20 g) were used. Hela cervical cancer cells were injected subcutaneously (1 x 10(7) cells/200 μL). Ten days after injection, the mice were divided into three groups (n=6), the A group of controls without any treatment, the B group receiving a single-treatment with Tmpyp4 (10 mg/kg, intratumor injection) and irradiation (blue laser, 108 J/cm(2)), and the C group given three-treatments with Tmpyp4 (10 mg/ kg, intratumor injection) and irradiation at intervals of two days. After starting treatment, tumours were measured every two days, to assess growth. At 2 weeks after the last treatment of C group, tumour tissue and organs were collected from each mouse to evaluate tumor histology and organ damage. RESULTS: Tumour growth in C group was significantly inhibited compared with A and B groups (P <0.05), without any injury to the skin and internal organs. CONCLUSION:
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Authors | Ai-Hong Liu, Xuan Sun, Xiao-Qiang Wei, You-Zhong Zhang |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 14
Issue 9
Pg. 5371-4
( 2013)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 24175828
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Photosensitizing Agents
- Porphyrins
- tetra(4-N-methylpyridyl)porphine
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Topics |
- Animals
- Female
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use)
- Porphyrins
(therapeutic use)
- Tumor Burden
- Tumor Cells, Cultured
- Uterine Cervical Neoplasms
(drug therapy, pathology)
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