Abstract | PURPOSE: Microvesicles (MV) in the blood stream are associated with distant metastasis in cancer. Platelet or endothelial cell-related MV actively participate in thrombogenesis, which is an important step in cancer metastasis. This study investigated the correlations between MV levels of platelet-poor plasma and distant metastasis in lung cancer. METHODS: RESULTS: The level of CD142 + MV was significant (odds ratio 5.86, 95 % confidence interval 1.31-38.3) in predicting distant metastasis in lung cancer, and a cutoff value of 2.668 (after logarithm transformation) in the ROC curve had a specificity of 90 % and a sensitivity of 59 %. The presence of distant metastasis showed a significant correlation between CD144 + EMV and VEGF, but not between CD144 + EMV and CD42 + PMV or CD62P + PMV in lung cancer subjects. CONCLUSIONS:
|
Authors | Jo-Chi Tseng, Liang-Che Chang, Boy-Yiing Jiang, Yu-Chih Liu, Hung-Jie Chen, Chih-Teng Yu, Chung-Ching Hua |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 140
Issue 1
Pg. 61-7
(Jan 2014)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 24169761
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Aged
- Case-Control Studies
- Cytoplasmic Vesicles
(metabolism)
- Female
- Flow Cytometry
- Humans
- Lung Neoplasms
(blood, pathology)
- Male
- Neoplasm Metastasis
- ROC Curve
- Thromboplastin
(metabolism)
|