NR4A nuclear receptors in immunity and atherosclerosis.

Abstract

PURPOSE OF REVIEW:

To understand chronic inflammatory diseases such as atherosclerosis, we require in-depth knowledge on immune-cell differentiation, function of specific immune-cell subsets and endothelial cell-mediated extravasation. In this review, we summarize a number of very recent observations on the pivotal function of NR4A nuclear receptors in immunity and atherosclerosis.

RECENT FINDINGS:

NR4A nuclear receptors are involved in negative selection of thymocytes, Treg differentiation and the development of Ly6C monocytes. Nur77 and Nurr1 attenuate atherosclerosis in mice whereas NOR-1 aggravates vascular lesion formation.

SUMMARY:

These exciting, novel insights on the function of NR4A nuclear receptors in immunity, vascular cells and atherosclerosis will initiate a plethora of studies to understand the underlying molecular mechanisms, which will culminate in the identification of novel NR4A targets to modulate chronic inflammatory disease.

• Authors: Anouk A J Hamers, Richard N Hanna, Heba Nowyhed, Catherine C Hedrick, Carlie J M de Vries
• Journal: Current opinion in lipidology (Curr Opin Lipidol) Vol. 24 Issue 5 Pg. 381-5 (Oct 2013) ISSN: 1473-6535 [Electronic] England
• PMID: 24005216 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• NR4A1 protein, human
• NR4A2 protein, human
• Nr4a1 protein, mouse
• Nr4a2 protein, mouse
• Nuclear Receptor Subfamily 4, Group A, Member 1
• Nuclear Receptor Subfamily 4, Group A, Member 2

Topics

• Animals
• Atherosclerosis (immunology, pathology)
• Cell Differentiation (immunology)
• Endothelial Cells (immunology, pathology)
• Humans
• Mice
• Monocytes (immunology, pathology)
• Nuclear Receptor Subfamily 4, Group A, Member 1 (immunology)
• Nuclear Receptor Subfamily 4, Group A, Member 2 (immunology)
• T-Lymphocytes, Regulatory (immunology, pathology)