Trafficking of NMDA receptors during status epilepticus: therapeutic implications.

Abstract

We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.

• Authors: Claude G Wasterlain, David E Naylor, Hantao Liu, Jerome Niquet, Roger Baldwin
• Journal: Epilepsia (Epilepsia) Vol. 54 Suppl 6 Pg. 78-80 (Sep 2013) ISSN: 1528-1167 [Electronic] United States
• PMID: 24001081 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

Chemical References

• Receptors, N-Methyl-D-Aspartate
• N-Methylaspartate

Topics

• Animals
• Disease Models, Animal
• Hippocampus (metabolism, physiopathology)
• N-Methylaspartate (metabolism)
• Neurons (metabolism)
• Rats
• Receptors, N-Methyl-D-Aspartate (metabolism)
• Status Epilepticus (metabolism, physiopathology, therapy)