Abstract |
Central Hemodynamics from the New Positive-inotrope Substance Adibendan/An open dose-finding study We investigated the influence of Adibendan which is a new phophodiesterase inhibitor on central hemodynamics in an open dose-finding study. 10 patients with chronic heart failure NYHA II-IV (mean age 67 +/- 5 years) got Adibendan i.v. A maximum increase in cardiac index from 2.3 +/- 0.5 to 3.2 +/- 0.5 l/min.m2 (p less than 0.001) was seen after a cumulative dosage of 0.916 +/- 0.571 mg at a time interval of 107 +/- 43 min after injection of the first dosage of 0.125 mg. There was a pronounced increase in stroke volume index from 30 +/- 6 to 40 +/- 8 ml/m2 (p less than 0.01). Heart rate raised by 5% which was not significant. Systemic vascular resistance dropped by 30% from 1693 +/- 720 to 1177 +/- 292 dyn.s.cm-5 (p less than 0.05), pulmonary vascular resistance by 39% from 755 +/- 273 to 463 +/- 199 dyn.s.cm-5 (p less than 0.001). Blood pressure and right atrial pressure did not alter. Mean pulmonary artery pressure dropped by 14% from 37 +/- 7 to 32 +/- 11 mmHg. We conclude that Adibendan improves cardiac index markedly and causes a modest decrease in mean pulmonary artery pressure.
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Authors | P Peters, F Saborowski, E May, M Schneider |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 40
Issue 6
Pg. 666-8
(Jun 1990)
ISSN: 0004-4172 [Print] Germany |
Vernacular Title | Zentrale Hämodynamik unter der neuen positiv inotropen Substanz Adibendan. Daten einer Dosisfindungsstudie. |
PMID | 2397002
(Publication Type: Journal Article)
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Chemical References |
- Benzimidazoles
- Imidazoles
- Oxindoles
- Vasodilator Agents
- adibendan
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Topics |
- Aged
- Benzimidazoles
- Blood Pressure
(drug effects)
- Cardiac Output
(drug effects)
- Chronic Disease
- Female
- Heart Failure
(drug therapy)
- Heart Rate
(drug effects)
- Hemodynamics
(drug effects)
- Humans
- Imidazoles
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Oxindoles
- Pulmonary Circulation
(drug effects)
- Stroke Volume
(drug effects)
- Vasodilator Agents
(administration & dosage, therapeutic use)
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