Abstract |
N-lauroyl chitosan (NLCS) conjugates with different degrees of substitution (DS) of lauroyl group were synthesized and used to prepare surface modified poly(lactic-co-glycolic) acid (NLCS-PLGA) nanoparticles via hydrophobic interaction and ionic bond force. NLCS-PLGA nanoparticles had spherical shape with shell-core structure and exhibited the smallest size and narrowest size distribution when DS of lauroyl group of NLCS was 8.5%. Adriamycin (ADR), as a model antitumor drug, was loaded into NLCS-PLGA nanoaprticles and its initial burst release from PLGA nanoparticles was significantly reduced. MTT assay showed that NLCS-2-PLGA nanoaprticles evidently enhanced cytotoxicity of ADR against drug-resistant breast cancer MCF-7/ADR cells, both compared to free ADR and ADR-loaded PLGA nanoparticles. Moreover, cell-live images showed that the cellular uptake and nuclear location of ADR in MCF-7/ADR cells were significantly enhanced by loading of NLCS-2-PLGA nanoparticles. In conclusion, this novel carrier of anticancer drugs has the potential to overcome drug resistance in cancer cells.
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Authors | Jing Li, Ping Zhou, Yan Wang, Hongli Chen, Cong Zhang, Rongshan Li, Xiaoying Yang, Yinsong Wang |
Journal | Journal of microencapsulation
(J Microencapsul)
Vol. 31
Issue 3
Pg. 203-10
( 2014)
ISSN: 1464-5246 [Electronic] England |
PMID | 23937210
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Carriers
- Polylactic Acid-Polyglycolic Acid Copolymer
- Polyglycolic Acid
- Lactic Acid
- Doxorubicin
- Chitosan
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Topics |
- Breast Neoplasms
(drug therapy, metabolism, pathology)
- Cell Line, Tumor
- Chitosan
(chemistry, pharmacology)
- Doxorubicin
(chemistry, pharmacology)
- Drug Carriers
(chemical synthesis, chemistry, pharmacology)
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Humans
- Lactic Acid
(chemistry, pharmacology)
- Polyglycolic Acid
(chemistry, pharmacology)
- Polylactic Acid-Polyglycolic Acid Copolymer
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