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N-lauroyl chitosan surface-modified PLGA nanoparticles as carrier for adriamycin to overcome cancer drug resistance.

Abstract
N-lauroyl chitosan (NLCS) conjugates with different degrees of substitution (DS) of lauroyl group were synthesized and used to prepare surface modified poly(lactic-co-glycolic) acid (NLCS-PLGA) nanoparticles via hydrophobic interaction and ionic bond force. NLCS-PLGA nanoparticles had spherical shape with shell-core structure and exhibited the smallest size and narrowest size distribution when DS of lauroyl group of NLCS was 8.5%. Adriamycin (ADR), as a model antitumor drug, was loaded into NLCS-PLGA nanoaprticles and its initial burst release from PLGA nanoparticles was significantly reduced. MTT assay showed that NLCS-2-PLGA nanoaprticles evidently enhanced cytotoxicity of ADR against drug-resistant breast cancer MCF-7/ADR cells, both compared to free ADR and ADR-loaded PLGA nanoparticles. Moreover, cell-live images showed that the cellular uptake and nuclear location of ADR in MCF-7/ADR cells were significantly enhanced by loading of NLCS-2-PLGA nanoparticles. In conclusion, this novel carrier of anticancer drugs has the potential to overcome drug resistance in cancer cells.
AuthorsJing Li, Ping Zhou, Yan Wang, Hongli Chen, Cong Zhang, Rongshan Li, Xiaoying Yang, Yinsong Wang
JournalJournal of microencapsulation (J Microencapsul) Vol. 31 Issue 3 Pg. 203-10 ( 2014) ISSN: 1464-5246 [Electronic] England
PMID23937210 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Carriers
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Doxorubicin
  • Chitosan
Topics
  • Breast Neoplasms (drug therapy, metabolism, pathology)
  • Cell Line, Tumor
  • Chitosan (chemistry, pharmacology)
  • Doxorubicin (chemistry, pharmacology)
  • Drug Carriers (chemical synthesis, chemistry, pharmacology)
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Humans
  • Lactic Acid (chemistry, pharmacology)
  • Polyglycolic Acid (chemistry, pharmacology)
  • Polylactic Acid-Polyglycolic Acid Copolymer

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