Abstract | BACKGROUND: METHODS: A palatine partial-thickness mucosal flap was raised in 10 male-specific pathogen-free New Zealand White rabbits. Randomized into 2 groups of 5 animals each (control and HBOT), functional capillary density was measured preoperatively (baseline), and immediately postoperatively until day 21 using sidestream dark-field video microscopy. Ten HBOT sessions were administered over the course of 2 weeks at 2.5 atmospheres (2.5 bar O2 /90 minutes). RESULTS: Repeated measures analysis of variance was used to compare the HBOT and control group on the sequential functional capillary density measurements. A significant interaction effect was present between time and group (F [8, 64] = 9.60; p < .0001) resulting from a significant increase in microcirculation in the HBOT group relative to the control group on days 7, 9, and 11. CONCLUSION: Our results suggest that HBOT is capable of advancing wound vascular regeneration in healing keratinized oral mucosal flaps.
|
Authors | Renée Helmers, Dan M J Milstein, Robert A van Hulst, Jan de Lange |
Journal | Head & neck
(Head Neck)
Vol. 36
Issue 9
Pg. 1241-7
(Sep 2014)
ISSN: 1097-0347 [Electronic] United States |
PMID | 23913629
(Publication Type: Journal Article)
|
Copyright | Copyright © 2013 Wiley Periodicals, Inc. |
Topics |
- Animals
- Hyperbaric Oxygenation
- Male
- Microcirculation
(physiology)
- Mouth Mucosa
(blood supply, surgery)
- Neovascularization, Physiologic
- Rabbits
- Surgical Flaps
(blood supply)
- Time Factors
- Wound Healing
|