A single-center retrospective cohort study was conducted, involving 354 cases from 395 Chinese in-patients who had
ischemic stroke with prior ICH history in Beijing Chaoyang hospital from May 1, 2005 to October 31, 2010. Survivors were followed by telephone interviews for 12-60 months. Cox regression and Kaplan-Meier plot analysis were used to evaluate the effect of 20 mg/day
atorvastatin on
cerebral infarction and ICH recurrence.
RESULTS: The overall rate of
stroke recurrence was lower in the 20 mg/day
atorvastatin group (χ(2)=6.687, p=0.022) than in the control group. The incidence of
cerebral hemorrhage was increased by 20 mg/day
atorvastatin for
ischemic stroke cases with a history of ICH compared to those not receiving the
drug, but the difference was not significant [hazard ratio (HR)=1.097, 95% confidence interval (CI)=0.800-1.243, p=0.980]. The incidence of
ischemic stroke recurrence was significantly reduced in subjects receiving
atorvastatin (HR=0.723, 95% CI=0.578-0.862, p=0.028), and the mean duration of all
stroke recurrences was significantly prolonged, compared with those not exposed to the
drug (χ(2)=5.351, p=0.021). The mean duration of ICH recurrence appeared to have shortened with
atorvastatin, but the difference was not significant (χ(2)=0.680, p=0.480), and the mean duration of
cerebral infarction recurrence was significantly prolonged (χ(2)=8.312, p=0.004).
CONCLUSIONS: