Abstract |
We aimed to investigate the clinical value of persistent but downgraded vesicoureteral reflux (VUR) after dextranomer/ hyaluronic acid (Dx/HA) injection in children. The medical records of 128 children (195 ureters) who underwent Dx/HA injections for VUR were reviewed. The incidences of pre- and post-operative febrile urinary tract infections (UTIs) were analyzed in children with or without persistent VUR on voiding cystourethrography (VCUG) 3 months postoperatively. The surgical results of VUR persistent children who underwent a single additional injection were assessed. The VUR resolved completely in 100 ureters (51.3%), was persistent in 95 ureters, and newly developed in 2 ureters. The incidence of pre/post-operative febrile UTIs were 0.35 ± 0.39 per year and 0.07 ± 0.32 per year in VUR resolved children (P < 0.001), and 0.76 ± 1.18 per year and 0.20 ± 0.61 per year in VUR persistent children (P < 0.001). A single additional Dx/HA injection (44 ureters) resolved VUR in 29 ureters (65.9%), and also reduced the VUR to grade I in 7 ureters (15.9%), II in 4 (9.1%), and III in 4 (9.1%). Even in children with persistent VUR after Dx/HA injection, the incidence of febrile UTIs decreased markedly. The VUR grade significantly decreases after single additional Dx/HA injection.
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Authors | Minki Baek, Min Young Kang, Hahn-Ey Lee, Kwanjin Park, Hwang Choi |
Journal | Journal of Korean medical science
(J Korean Med Sci)
Vol. 28
Issue 7
Pg. 1060-4
(Jul 2013)
ISSN: 1598-6357 [Electronic] Korea (South) |
PMID | 23853490
(Publication Type: Journal Article)
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Chemical References |
- Dextrans
- dextranomer
- Hyaluronic Acid
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Topics |
- Antibiotic Prophylaxis
- Child
- Child, Preschool
- Dextrans
(therapeutic use)
- Female
- Fever
(complications, epidemiology)
- Humans
- Hyaluronic Acid
(therapeutic use)
- Incidence
- Male
- Retrospective Studies
- Treatment Outcome
- Urinary Tract Infections
(complications, drug therapy, epidemiology)
- Vesico-Ureteral Reflux
(drug therapy, surgery)
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